Recombination Rate Variation, Hitchhiking, and Demographic History Shape Deleterious Load in Poplar
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چکیده
منابع مشابه
Recombination and hitchhiking of deleterious alleles.
When new advantageous alleles arise and spread within a population, deleterious alleles at neighboring loci can hitchhike alongside them and spread to fixation in areas of low recombination, introducing a fixed mutation load. We use branching processes and diffusion equations to calculate the probability that a deleterious allele hitchhikes and fixes alongside an advantageous mutant. As expecte...
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Deleterious mutations present a significant obstacle to adaptive evolution. Deleterious mutations can inhibit the spread of linked adaptive mutations through a population; conversely, adaptive substitutions can increase the frequency of linked deleterious mutations and even result in their fixation. To assess the impact of adaptive mutations on linked deleterious mutations, we examined the dist...
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Causes and Consequences of Recombination Rate Variation in Drosophila by Laurie Sherie Stevison Department of Biology Duke University Date:_______________________ Approved: ___________________________ Mohamed Noor, Supervisor ___________________________ Corbin D. Jones ___________________________ Thomas Mitchell-Olds ___________________________ Gregory Wray ___________________________ David Mac...
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ژورنال
عنوان ژورنال: Molecular Biology and Evolution
سال: 2016
ISSN: 0737-4038,1537-1719
DOI: 10.1093/molbev/msw169